If I had to pick one, I'd probably settle on Maniac. It's very hard to go wrong with runing this and it pretty much comes down to a matter of personal preference or filling gaps in your gear. There's also Smite for the 20% stun (which doesn't last as long on elites) which helps you out a bit with reducing damage, and then there's Vanguard for the movement speed bonus. Sidearm also adds nice damage but I don't like the unpredictability of it, as sometimes it shoots off and hits a treasure goblin I didn't want to deal with yet. If your weapon is kind of weak or you just don't have a problem topping off your health, a far more popular option is Maniac for the +20% damage. I'm low on Life on Hit gear but have a decent DPS weapon for Act 1, so I've got it runed with Triumph so that I have a fairly steady stream of life coming in (6% of my max health) and can save money on potions. I'll try to explain why I've chosen what I did, and what other options I've seen.įrenzy gives high single-target DPS, which you'll need. I've seen a few different builds bandied about, but most will look pretty similar to what I've got below, other than maybe a rune or a passive different. As your gear progresses, you'll find that you can make your build a little more offense-oriented, so don't be afraid to experiment and swap in some more powerful offensive abilities if you find that your survivability is doing fine!
The Barbarian is a very gear-oriented class, and our defensive skills can make up for a lot of shortcomings in gear. The advice below is geared towards Act 1, though with minor tweaks it holds up pretty well in Act 2 and Acts 3 & 4 (see bottom of post). You're going to need armor and resistances.
Strength/Vitality gear, though it got you through Normal, Nightmare, and probably even Hell just fine, won't cut it anymore. Novarg left a solid answer that I can't confirm since I don't play anymore, but seems to address the changes in later patches that allow for a more damage-oriented build. With the changes to defensive skills such as Leap and War Cry, and in general making Inferno easier, some of this advice needs reevaluation. Note: This was written prior to patch 1.05.
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